The American Osteopathic Association of Prolotherapy Regenerative Medicine

Teaching Physicians Prolotherapy Since 1938
Committed to the long term education of Prolotherapy

Affiliate of the American Osteopathic Association
303 S. Ingram Court - Middletown, DE 19709

Interested in becoming board certified in Prolotherapy?
Click here.



To the American Osteopathic Association of Prolotherapy Regenerative Medicine

We are dedicated toward improving the practice of, and disseminating knowledge about Prolotherapy.


What is Prolotherapy?

Prolotherapy is the stimulation of the formation of fibrous connective tissue of the body, in a specific location by the specific application of a regenerative modality.

Advanced Treatment for Pain Arising From

• Whiplash Injuries and Neck Pain
• Knee Conditions, Ankle & Foot Pain & Plantar Fasciitis
•  Shoulder Pain, Rotator Cuff Tears/Tendinopathy
• Tennis and Golfer's Elbow, Wrist Pain
• Herniated Disc Pain
• Pain from Osteoarthritis
• Mid and Low Back Pain
•  Varicose Vein Therapies

How Does Prolotherapy Work?

iStock_000014030479Small (2)
Prolotherapy has as its current primary applications in the treatment of:
  • Unstable joints (often associated with backaches and other pain)
  • Venous Abnormalities (eg. Varicose & spider veins),
  • Hernia, and Hemorrhoids.

With a precise injection of a mild irritant solution directly on the site of the torn or stretched ligament or tendon, Prolotherapy creates a mild, controlled injury that stimulates the body’s natural healing mechanisms to lay down new tissue on the weakened area. The mild inflammatory response that is created by the injection encourages growth of new ligament or tendon fibers, resulting in a tightening of the weakened structure. Additional treatments repeat this process, allowing a gradual buildup of tissue to restore the original strength to the area. Injection of varicose veins and other similar abnormalities creates a mild inflammatory response causing them to contract so that they become smaller or even vanish.

Can Prolotherapy help everyone?

Each patient must be evaluated thoroughly with patient history, physical exam, X-ray exam, and full laboratory work up before treatment will be administered. With this information, your physician can evaluate your potential success with this therapy. Success depends on factors which include the history of damage to the patient, the patient’s overall health and ability to heal, and any underlying nutritional deficiencies that would impede the healing process.

What areas of the body can be treated?

This form of therapy can be used to treat dislocation of the joints, knee pain, shoulder pain, Temporal Mandibular Joint dysfunction, Carpal Tunnel Syndrome, and disc problems at any level of the spine. The therapy affects only the area treated and does not cause any problem in any other area. Spider veins, abnormal or bulging veins and other similar conditions can be treated on the legs, feet, hands, arms, breast, face, and most other areas.


How often do I need these treatments?

The treatments should be administered every one, two, or three weeks, as determined by your treating physician. Vein treatments are usually scheduled four or more weeks apart.  The American Osteopathic Association of Prolotherapy Regenerative Medicine, Inc. is dedicated toward improving the practice of, and disseminating knowledge about Prolotherapy.  (Previously known as Sclerotherapy)

We now have an updated informational brochure available for purchase!